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Welcome to our group Vaughan Lab Group! A space for us to connect and share with each other. Start by posting your thoughts, sharing media, or creating a poll.
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Projects
Below is a brief overview of our ongoing projects and research focuses in the Vaughan Lab.
Niemann Pick Type C Disease
Purkinje Cell Degeneration and Lipid Accumulation in NPC Mice
(Klein et al. 2014, Pediatric Endocrinology Reviews)
NPC1 Pathogenic Mutations in Six Ethnic Groups
(Chiorean, Garver, & Meyre 2020, Scientific Reports)
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Study of cellular mechanisms regulating intracellular cholesterol transport and lysosomal function
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Structural and functional analysis of novel cholesterol transport proteins
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Study of cellular mechanisms regulating STING activation in NPC disease
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Mouse studies investigating the effectiveness of disease-modifying molecules for the treatment of NPC disease
Pancreatic Cancer
Stepwise Progression of PDAC Carcinogenesis from PanIN.
(Orth et al. 2019, Radiat Oncol)
Structure and Function of the Nuclear Lamina
(Capell & Collins 2006, Nature Reviews)
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Study of cellular mechanisms regulating mitotic progression and nuclear stability
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Compound screening for small molecule inhibitors of kinase involved in nuclear blebbing
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Study of cellular mechanisms regulating STING activation in pancreatic cancer models
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Mouse studies investigating the effectiveness of small molecules for the treatment of pancreatic cancer
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