Publications
Research Articles
Sterling FR, D'Amico J, Brumfield AM, Huegel KL, Vaughan PS, Morris K, Schwarz S, Joyce MV, Boggess B, Champion MM, Maciuba K, Allen P, Marasco E, Koch G, Gonzalez P, Hodges S, Leahy S, Gerstbauer E, Hinchcliffe EH, Vaughan KT. StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival. J Cell Sci. 2023 Mar 1;136(5):jcs260662. doi: 10.1242/jcs.260662. Epub 2023 Mar 2. PMID: 36861884; PMCID: PMC10203878.
Wehrmann ZT, Hulett TW, Huegel KL, Vaughan KT, Wiest O, Helquist P, Goodson H. Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts. PLoS One. 2012;7(10):e48561. doi: 10.1371/journal.pone.0048561. Epub 2012 Oct 29. PMID: 23144769; PMCID: PMC3483179.
Kasuboski JM, Bader JR, Vaughan PS, Tauhata SB, Winding M, Morrissey MA, Joyce MV, Boggess W, Vos L, Chan GK, Hinchcliffe EH, Vaughan KT. Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores. Mol Biol Cell. 2011 Sep;22(18):3318-30. doi: 10.1091/mbc.E11-03-0213. Epub 2011 Jul 20. PMID: 21775627; PMCID: PMC3172258.
Bader JR, Kasuboski JM, Winding M, Vaughan PS, Hinchcliffe EH, Vaughan KT. Polo-like kinase1 is required for recruitment of dynein to kinetochores during mitosis. J Biol Chem. 2011 Jun 10;286(23):20769-77. doi: 10.1074/jbc.M111.226605. Epub 2011 Apr 20. PMID: 21507953; PMCID: PMC3121523.
Hornick JE, Mader CC, Tribble EK, Bagne CC, Vaughan KT, Shaw SL, Hinchcliffe EH. Amphiastral mitotic spindle assembly in vertebrate cells lacking centrosomes. Curr Biol. 2011 Apr 12;21(7):598-605. doi: 10.1016/j.cub.2011.02.049. PMID: 21439826; PMCID: PMC3075362.
Collins ES, Hornick JE, Durcan TM, Collins NS, Archer W, Karanjeet KB, Vaughan KT, Hinchcliffe EH. Centrosome biogenesis continues in the absence of microtubules during prolonged S-phase arrest. J Cell Physiol. 2010 Nov;225(2):454-65. doi: 10.1002/jcp.22222. PMID: 20458743; PMCID: PMC2930098.
Towns WL, Tauhata SB, Vaughan PS, Vaughan KT. Transfection-induced defects in dynein-driven transport: evidence that ICs mediate cargo-binding. Cell Motil Cytoskeleton. 2009 Feb;66(2):80-9. doi: 10.1002/cm.20327. PMID: 19061245; PMCID: PMC2644063.
Whyte J, Bader JR, Tauhata SB, Raycroft M, Hornick J, Pfister KK, Lane WS, Chan GK, Hinchcliffe EH, Vaughan PS, Vaughan KT. Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol. 2008 Dec 1;183(5):819-34. doi: 10.1083/jcb.200804114. Epub 2008 Nov 24. PMID: 19029334; PMCID: PMC2592828.
Hornick JE, Bader JR, Tribble EK, Trimble K, Breunig JS, Halpin ES, Vaughan KT, Hinchcliffe EH. Live-cell analysis of mitotic spindle formation in taxol-treated cells. Cell Motil Cytoskeleton. 2008 Aug;65(8):595-613. doi: 10.1002/cm.20283. PMID: 18481305; PMCID: PMC2753270.
Durcan TM, Halpin ES, Casaletti L, Vaughan KT, Pierson MR, Woods S, Hinchcliffe EH. Centrosome duplication proceeds during mimosine-induced G1 cell cycle arrest. J Cell Physiol. 2008 Apr;215(1):182-91. doi: 10.1002/jcp.21298. PMID: 17960592; PMCID: PMC2764247.
Deacon SW, Serpinskaya AS, Vaughan PS, Lopez Fanarraga M, Vernos I, Vaughan KT, Gelfand VI. Dynactin is required for bidirectional organelle transport. J Cell Biol. 2003 Feb 3;160(3):297-301. doi: 10.1083/jcb.200210066. Epub 2003 Jan 27. PMID: 12551954; PMCID: PMC2172679.
Vaughan PS, Miura P, Henderson M, Byrne B, Vaughan KT. A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport. J Cell Biol. 2002 Jul 22;158(2):305-19. doi: 10.1083/jcb.200201029. Epub 2002 Jul 15. PMID: 12119357; PMCID: PMC2173134.
Susalka SJ, Nikulina K, Salata MW, Vaughan PS, King SM, Vaughan KT, Pfister KK. The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain. J Biol Chem. 2002 Sep 6;277(36):32939-46. doi: 10.1074/jbc.M205510200. Epub 2002 Jun 20. PMID: 12077152.
Reviews
Vaughan KT, Hinchcliffe EH. Molecular motors in mitosis. Introduction. Semin Cell Dev Biol. 2010 May;21(3):247. doi: 10.1016/j.semcdb.2010.02.009. Epub 2010 Feb 26. PMID: 20219691.
Bader JR, Vaughan KT. Dynein at the kinetochore: Timing, Interactions and Functions. Semin Cell Dev Biol. 2010 May;21(3):269-75. doi: 10.1016/j.semcdb.2009.12.015. Epub 2010 Jan 4. PMID: 20045078; PMCID: PMC2860529.
Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB. Cytoplasmic dynein nomenclature. J Cell Biol. 2005 Nov 7;171(3):411-3. doi: 10.1083/jcb.200508078. Epub 2005 Oct 31. PMID: 16260502; PMCID: PMC2171247.
Vaughan KT. TIP maker and TIP marker; EB1 as a master controller of microtubule plus ends. J Cell Biol. 2005 Oct 24;171(2):197-200. doi: 10.1083/jcb.200509150. PMID: 16247021; PMCID: PMC2171192.
Vaughan KT. Microtubule plus ends, motors, and traffic of Golgi membranes. Biochim Biophys Acta. 2005 Jul 10;1744(3):316-24. doi: 10.1016/j.bbamcr.2005.05.001. PMID: 15950296.
Vaughan KT. Surfing, regulating and capturing: are all microtubule-tip-tracking proteins created equal? Trends Cell Biol. 2004 Sep;14(9):491-6. doi: 10.1016/j.tcb.2004.07.011. PMID: 15350977.